Salmon DNA for Facial Rejuvenation: What the Research Reveals
Salmon-derived DNA—often referred to as polydeoxyribonucleotides (PDRN) or “salmon sperm extract”—has risen in popularity in dermatology and aesthetic medicine. While many treatments involve injections, microneedling facials using salmon DNA are becoming an increasingly sought-after option for those seeking natural, regenerative skin therapies. Below is a science-led overview of what studies show about salmon DNA in skincare—and an exciting update about this treatment coming soon to our clinic.
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What Is Salmon DNA (PDRN)?
Salmon DNA refers to purified DNA fragments extracted from salmon sperm or roe, used in clinical aesthetic treatments. Rich in nucleotides and polynucleotides, these compounds mimic human DNA closely—making them biologically compatible and potentially effective for skin repair (skintypesolutions.com, marieclaire.com).
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How It Works: Mechanisms of Action
1. Activation of Fibroblasts & Collagen Synthesis
Salmon DNA fragments act through binding to adenosine A₂A receptors on fibroblasts, leading to heightened collagen and extracellular matrix protein production. One study showed fibroblast proliferation increased by 132% and collagen type I synthesis rose by 164% within 12 weeks post-treatment (thelondonprpclinic.com).
2. Hydration and Moisture Retention
PDRN molecules exhibit hygroscopic properties, helping the skin retain water—up to 1,000× their own weight. This enhances moisturisation, leading to plumper, more elastic skin.
3. Anti-inflammatory and Healing Support
Studies have shown that salmon-derived DNA reduces inflammatory cytokine activity and speeds up tissue repair. It has been used in clinical settings to improve post-surgical wound healing and reduce scarring (medpedia.health).
4. Protection Against UV-Induced DNA Damage
Salmon DNA contains enzymes that assist in DNA repair and reduce oxidative stress from UV exposure, potentially protecting the skin from sun-related ageing.
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Evidence from Clinical Studies
Injected Treatments (PDRN Injections)
• A 2022 randomised split-face study in Korea (n = 27) compared intradermal injections of PDRN with hyaluronic acid. While improvements in pore volume and skin roughness were observed, statistically significant overall aesthetic improvement was not achieved (drrachelho.com).
• A 2018 trial (n = 44) combining PDRN with fractional laser therapy found enhanced wound-healing and scar improvement post-thyroid surgery.
• A 2016 case series (n = 5) showed gains in skin thickness, tone, pore size reduction, and wrinkle improvement after a series of injections.
Microneedling with Salmon DNA
Microneedling creates micro-channels in the skin, enhancing the penetration of active ingredients. Studies suggest that pairing microneedling with PDRN can:
• Increase collagen and elastin production
• Accelerate tissue repair
• Improve hydration and texture
• Enhance under-eye rejuvenation outcomes
This combination may offer similar benefits to injectable treatments but with reduced invasiveness and downtime.
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Commonly Reported Benefits
• Firmer, more elastic skin
• Enhanced hydration and moisture retention
• Smoother texture, reduced pore size, and diminished fine lines
• Calming of inflammation and faster healing
• Improved pigmentation and scar appearance
• Particularly noticeable improvements under the eyes and on delicate areas
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Limitations & Considerations
• Topical absorption is limited: Microneedling or injection delivery ensures better results.
• Allergic reactions possible: Individuals with fish allergies should avoid this treatment.
• Ethical sourcing: Products should be responsibly sourced from sustainable fisheries.
• Professional oversight required: These are medical-grade treatments that should only be carried out by trained professionals.
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Coming Soon to Our Psychodermatology Clinic
We are pleased to announce that Salmon DNA Microneedling Facials will soon be available at our clinic as of 4th of August. This treatment combines microneedling technology with the regenerative properties of salmon DNA (PDRN) to:
• Boost collagen production
• Improve skin texture and elasticity
• Hydrate and soothe sensitive or stressed skin
• Support overall skin rejuvenation at a cellular level
Our psychodermatology approach integrates skin health with emotional wellbeing, aiming to restore confidence alongside skin vitality. The Salmon DNA facial will be offered as part of our advanced regenerative treatments, tailored to individual skin needs.
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References
1. Medpedia Health – Mechanisms and anti-inflammatory effects of salmon DNA
https://medpedia.health/11592/the-science-behind-salmon-dna-in-skincare-how-it-promotes-skin-health/
2. Dr Rachel Ho – Clinical studies on PDRN injections
https://www.drrachelho.com/blog/salmon-sperm-facial-injections/
3. London PRP Clinic – Under-eye and full-face outcomes
https://www.thelondonprpclinic.com/blogs/salmon-dna-for-facial-and-under-eye-treatments
4. Fox Pharma – Moisturisation and UV protection
https://foxpharma.co.uk/blog/how-to-harness-the-power-of-salmon-dna/
5. Marie Claire – Overview of PDRN in skincare